کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2084893 1545398 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of dye as tracer of drug release from medicated chewing gums
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Use of dye as tracer of drug release from medicated chewing gums
چکیده انگلیسی

The evaluation of the potential use of a dye as indicator of in vivo drug release from a medicated chewing gum is described. The device is a three-layer tablet obtained by direct compression consisting of a gum core and two external protective soluble layers to prevent gum adhesion to the punches of the tableting machine. The active ingredient and a colour are contained in the gum core. To evaluate the drug and the dye release from the formulations, a chew-out study was performed by a panel of volunteers. The results obtained suggest that the use of a dye could be useful to indicate the chewing time necessary to complete drug delivery from medicated chewing gums.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 68, Issue 3, March 2008, Pages 811–817
نویسندگان
, , , , , ,