کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2085481 1545368 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamic and static curing of ethylcellulose:PVA–PEG graft copolymer film coatings
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Dynamic and static curing of ethylcellulose:PVA–PEG graft copolymer film coatings
چکیده انگلیسی

When using aqueous polymer dispersions for the preparation of controlled-release film coatings, instability during long-term storage can be a crucial concern. Generally, a thermal after treatment is required to assure sufficient polymer particle coalescence. This curing step is often performed under static conditions in an oven, which is a time-consuming and rather cumbersome process. Dynamic curing in the fluidized bed presents an attractive alternative. However, yet little is known on the required conditions, in particular: temperature, time, and relative humidity, to provide stable film structures. The aim of this study was to better understand the importance of these key factors and to evaluate the potential of dynamic curing compared with that of static curing. Recently proposed ethylcellulose:poly(vinyl alcohol)–poly(ethylene glycol) graft copolymer (PVA–PEG graft copolymer) dispersions were coated on theophylline and metoprolol succinate-loaded starter cores, exhibiting different osmotic activity. Importantly, processing times as short as 2 h were found to be sufficient to provide long-term stable films, even upon open storage under stress conditions. For instance, 2-h dynamic curing at 57 °C and 15% relative humidity are assuring stable film structures in the case of theophylline matrix cores coated with 15% ethylcellulose:PVA–PEG graft copolymer 85:15. Importantly, the approach is also applicable to other types of drugs and starter cores, and the underlying drug release mechanisms remain unaltered.

Long term stable, coated pellets with predominantly diffusion controlled drug release can be prepared via dynamic or static curing.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 78, Issue 3, August 2011, Pages 455–461
نویسندگان
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