Gentamicin bound to the nanofibre microdispersed oxidized cellulose in the treatment of deep surgical site infections

SummaryThe aim of this experimental in vivo study was to examine the effect of topically-used gentamicin bound to microdispersed oxidized cellulose (MDOC) in nanofibre form in the treatment of deep surgical site infections and to compare it with Garamycin Schwamm®. Twelve domestic swine were used in a model of a full-thickness infected dermal wound. The effectiveness of both forms of gentamicin were tested in wound infections caused by Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effectiveness of gentamicin-MDOC and Garamycin Schwamm® were comparable according to microbiological culture findings, with no statistically significant differences. When macroscopically assessed, 100% of the infected wounds treated by gentamicin-MDOC were without signs of infection, compared with only 16.7% when Garamycin Schwamm® was used and this was of statistical significance. Therefore when combined with a nanofibre MDOC carrier, topically-used gentamicin is rendered more effective for the treatment of full-thickness skin infections.