کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2088779 1545758 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
A novel nanoparticulate adjuvant for immunotherapy with Lolium perenne
چکیده انگلیسی

Specific immunotherapy implies certain drawbacks which could be minimized by the use of appropriate adjuvants, capable of amplifying the right immune response with minimal side effects. In this context, previous studies of our group have demonstrated the adjuvant capacity of Gantrez® AN nanoparticles, which can effectively enhance the immune response. In this work, two types of nanoparticles (with and without LPS of Brucella ovis as immunomodulator) with encapsulated Lolium perenne extract are tested in a model of sensitized mice to this allergenic mixture. The results we obtained showed that Lolium–Gantrez® nanoparticles with LPS of B. ovis were able to induce significative Th1 responses, characterized by the IgG2a isotype. Furthermore, in the challenge experiment of the sensitized mice, differences in the mortality rate and in the mMCP-1 levels were found between the treated groups and the control.Under the experimental conditions of this model of pre-sensitized mice to L. perenne, Gantrez® AN nanoparticles appeared to be a good strategy for immunotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Immunological Methods - Volume 348, Issues 1–2, 31 August 2009, Pages 1–8
نویسندگان
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