کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2089578 1545788 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A modified α-galactosyl ceramide for staining and stimulating natural killer T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
A modified α-galactosyl ceramide for staining and stimulating natural killer T cells
چکیده انگلیسی

CD1d presentation of α-galactosyl ceramides to natural killer T cells has been a focal point of the study of regulatory T cells. KRN7000, an α-galactosyl ceramide originally generated from structure activity studies of antitumor properties of marine sponge glycolipids, is currently the most commonly used agonist ligand and is used to stain NKT cells. However, this glycolipid suffers from poor solubility and availability. We have developed an α-galactosyl ceramide with improved solubility over KRN7000 that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Immunological Methods - Volume 312, Issues 1–2, 30 May 2006, Pages 34–39
نویسندگان
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