کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2092833 1081819 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibacterial, antifungal, and antiviral activities of some flavonoids
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Antibacterial, antifungal, and antiviral activities of some flavonoids
چکیده انگلیسی

SummaryAntibacterial and antifungal activities of six plant-derived flavonoids representing two different structural groups were evaluated against standard strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and their drug-resistant isolates, as well as fungi (Candida albicans, C. krusei) using the microdilution broth method. Herpes simplex virus Type-1 and Parainfluenza-3 virus were employed for antiviral assessment of the flavonoids using Madin-Darby bovine kidney and Vero cell lines. Ampicillin, gentamycin, ofloxacin, levofloxacin, fluconazole, ketoconazole, acyclovir, and oseltamivir were used as the control agents. All tested compounds (32–128 μg/ml) showed strong antimicrobial and antifungal activities against isolated strains of P. aeruginosa, A. baumanni, S. aureus, and C. krusei. Rutin, 5,7-dimethoxyflavanone-4′-O-β-d-glucopyranoside and 5,7,3′-trihydroxy-flavanone-4′-O-β-d-glucopyranoside (0.2–0.05 μg/ml) were active against PI-3, while 5,7-dimethoxyflavanone-4′-O-[2″-O-(5‴-O-trans-cinnamoyl)-β-d-apiofuranosyl]-β-d-glucopyranoside (0.16–0.2 μg/ml) inhibited potently HSV-1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbiological Research - Volume 165, Issue 6, 20 August 2010, Pages 496–504
نویسندگان
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