کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2093253 | 1081949 | 2016 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal](/preview/png/2093253.png)
• In skeletal muscles, primary cilia are associated with quiescent satellite cells
• Primary cilia disassemble when satellite cells enter the cell cycle
• Primary cilia reassemble preferentially in self-renewing satellite cells
• Disruption of primary cilia reassembly impairs satellite cell self-renewal
SummaryRegeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative diseases. Satellite cell self-renewal is essential for long-term tissue homeostasis, and previous work has identified a number of external cues that control this process. However, little is known of the possible intrinsic control mechanisms of satellite cell self-renewal. Here, we show that quiescent satellite cells harbor a primary cilium, which is rapidly disassembled upon entry into the cell cycle. Contrasting with a commonly accepted belief, cilia reassembly does not occur uniformly in cells exiting the cell cycle. We found that primary cilia reassemble preferentially in cells committed to self-renew, and disruption of cilia reassembly causes a specific deficit in self-renewing satellite cells. These observations indicate that primary cilia provide an intrinsic cue essential for satellite cell self-renewal.
Journal: - Volume 6, Issue 6, 14 June 2016, Pages 798–805