کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093384 1081956 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurovascular Recovery via Cotransplanted Neural and Vascular Progenitors Leads to Improved Functional Restoration after Ischemic Stroke in Rats
ترجمه فارسی عنوان
بازیابی عصبی عضلانی از طریق پیش سازهای عصبی و عروقی همتراپلند باعث بهبود ترمیم عملکردی پس از سکته مغزی ایسکمیک در موش صحرایی می شود.
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Neural and vascular progenitor cell cotransplantation therapy for ischemic stroke
• Better neurovascular recovery by cotransplanted progenitor cells in the infarct area
• Better infarction reduction and functional restoration by cotransplantation
• Neurovascular recovery likely mediated by neural production of growth/trophic factors

SummaryThe concept of the “neurovascular unit,” emphasizing the interactions between neural and vascular components in the brain, raised the notion that neural progenitor cell (NPC) transplantation therapy aimed at neural repair may be insufficient for the treatment of ischemic stroke. Here, we demonstrate that enhanced neurovascular recovery via cotransplantation of NPCs and embryonic stem cell-derived vascular progenitor cells (VPCs) in a rat stroke model is correlated with improved functional recovery after stroke. We found that cotransplantation promoted the survival, migration, differentiation, and maturation of neuronal and vascular cells derived from the cotransplanted progenitors. Furthermore, it triggered an increased generation of VEGF-, BDNF-, and IGF1-expressing neural cells derived from the grafted NPCs. Consistently, compared with transplantation of NPCs alone, cotransplantation more effectively improved the neurobehavioral deficits and attenuated the infarct volume. Thus, cotransplantation of NPCs and VPCs represents a more effective therapeutic strategy for the treatment of stroke than transplantation of NPCs alone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 3, Issue 1, 8 July 2014, Pages 101–114
نویسندگان
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