کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093545 1081965 2015 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fibrogenic Cell Plasticity Blunts Tissue Regeneration and Aggravates Muscular Dystrophy
ترجمه فارسی عنوان
پلاستیسیته سلول های فیبروژنیک، بازسازی سلول های پوستی را تقویت می کند و دیستروفی عضلانی را تقویت می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Regeneration declines as fibrosis increases in Duchenne muscular dystrophy (DMD)
• Myogenic, endothelial, and hematopoietic cells acquire fibrogenic plasticity in DMD
• This fibrogenic plasticity in DMD is induced by TGFβ and blunts muscle regeneration
• Fibrogenesis occurs through an intermediate mesenchymal progenitor multipotent state

SummaryPreservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy (DMD), skeletal muscle regenerative capacity declines gradually as fibrosis increases. Using genetically engineered tracing mice, we demonstrate that, in dystrophic muscle, specialized cells of muscular, endothelial, and hematopoietic origins gain plasticity toward a fibrogenic fate via a TGFβ-mediated pathway. This results in loss of cellular identity and normal function, with deleterious consequences for regeneration. Furthermore, this fibrogenic process involves acquisition of a mesenchymal progenitor multipotent status, illustrating a link between fibrogenesis and gain of progenitor cell functions. As this plasticity also was observed in DMD patients, we propose that mesenchymal transitions impair regeneration and worsen diseases with a fibrotic component.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 4, Issue 6, 9 June 2015, Pages 1046–1060
نویسندگان
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