کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093595 1081968 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic Activation of Hedgehog Signaling Unbalances the Rate of Neural Stem Cell Renewal by Increasing Symmetric Divisions
ترجمه فارسی عنوان
فعال سازی ژنتیک سیگنالینگ خارپشت ناشی از افزایش میزان سلول های بنیادی عصبی با افزایش تقارن متقارن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Ptc inactivation in the adult NSCs expands the NSC pool and depletes their progenyNeurogenesis blockade is related to the increase of NSC symmetric divisionPTC exerts a central role via NOTCH, in the regulation of adult NSC self-renewal

SummaryIn the adult brain, self-renewal is essential for the persistence of neural stem cells (NSCs) throughout life, but its regulation is still poorly understood. One NSC can give birth to two NSCs or one NSC and one transient progenitor. A correct balance is necessary for the maintenance of germinal areas, and understanding the molecular mechanisms underlying NSC division mode is clearly important. Here, we report a function of the Sonic Hedgehog (SHH) receptor Patched in the direct control of long-term NSC self-renewal in the subependymal zone. We show that genetic conditional activation of SHH signaling in adult NSCs leads to their expansion and the depletion of their direct progeny. These phenotypes are associated in vitro with an increase in NSC symmetric division in a process involving NOTCH signaling. Together, our results demonstrate a tight control of adult neurogenesis and NSC renewal driven by Patched.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 3, Issue 2, 12 August 2014, Pages 312–323
نویسندگان
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