کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093598 1081968 2014 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells
ترجمه فارسی عنوان
داکسی سایکلین باعث افزایش بقا و بهبود خود سلول های بنیادی پلورپوفتون می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی


• Doxycycline enhances human pluripotent ESC/iPSC survival and self-renewal
• Doxycycline-mediated survival effects are also shown in human neural stem cell (NSC)
• Doxycycline effects are not associated with its antibacterial action
• The doxycycline actions are mediated by direct activation of a PI3K-Akt signaling

SummaryWe here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 3, Issue 2, 12 August 2014, Pages 353–364
نویسندگان
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