کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093606 1081969 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through β-Catenin Signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
The PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through β-Catenin Signaling
چکیده انگلیسی


• Nephron progenitor cells require PI3K signaling for self-renewal
• Reduced PI3K activity enhances β-catenin-induced differentiation
• Nephron progenitor cells can differentiate prior to completion of epithelialization

SummaryNephron progenitor cells differentiate to form nephrons during embryonic kidney development. In contrast, self-renewal maintains progenitor numbers and premature depletion leads to impaired kidney function. Here we analyze the PI3K pathway as a point of convergence for the multiple pathways that are known to control self-renewal in the kidney. We demonstrate that a reduction in PI3K signaling triggers premature differentiation of the progenitors and activates a differentiation program that precedes the mesenchymal-to-epithelial transition through ectopic activation of the β-catenin pathway. Therefore, the combined output of PI3K and other pathways fine-tunes the balance between self-renewal and differentiation in nephron progenitors.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 4, Issue 4, 14 April 2015, Pages 551–560
نویسندگان
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