Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts

• The goal of osteogenesis imperfecta (OI) cell therapy is osteoblast replacement
• In utero transplantation (IUT) of bone marrow was conducted in OI mice
• Donor-derived osteoblasts were absent following bone marrow IUT
• Donor-derived hematopoietic cells included osteoclasts and osteal macrophages