کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2093828 1081980 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart
چکیده انگلیسی


• Sca1pos cells continuously generate cardiomyocytes during adult life
• Some Sca1pos cells are tightly associated with cardiomyocytes
• Sca1pos-derived cells show limited clonal expansion
• Pressure overload moderately increases the number of Sca1-derived cardiomyocytes

SummaryAlthough the mammalian heart is one of the least regenerative organs in the body, recent evidence indicates that the myocardium undergoes a certain degree of renewal to maintain homeostasis during normal aging. However, the cellular origin of cardiomyocyte renewal has remained elusive due to lack of lineage tracing experiments focusing on putative adult cardiac precursor cells. We have generated triple-transgenic mice based on the tet-cre system to identify descendants of cells that have expressed the stem cell marker Sca1. We found a significant and lasting contribution of Sca1-derived cells to cardiomyocytes during normal aging. Ischemic damage and pressure overload resulted in increased differentiation of Sca1-derived cells to the different cell types present in the heart. Our results reveal a source of cells for cardiomyocyte renewal and provide a possible explanation for the limited contribution of Sca1-derived cells to myocardial repair under pathological conditions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 1, Issue 5, 19 November 2013, Pages 397–410
نویسندگان
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