کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2095606 | 1082128 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy neonatal calves (Bos Taurus). A venous, a peripheral arterial, and a pulmonary arterial catheter were placed, and central venous, pulmonary, and systemic blood pressures and cardiac output were measured using thermodilution technique. Doxapram, but not theophylline, led to an immediate increase in respiratory rate (P ⤠0.01). The arterial pCO2 decreased to 27.1 ± 4.7 mm Hg within 30 sec after doxapram administration and to 46.3 ± 5.8 mm Hg within 120 min after theophylline administration (P < 0.0001). The systolic pulmonary pressure increased from 70 ± 8 mm Hg (mean ± SD) to 93 ± 19 mm Hg within 30 sec after doxapram, but decreased after theophylline. The pulmonary vascular resistance also increased after doxapram and decreased after theophylline (P < 0.01). Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO2 than theophylline. Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Theriogenology - Volume 73, Issue 5, 15 March 2010, Pages 612-619
Journal: Theriogenology - Volume 73, Issue 5, 15 March 2010, Pages 612-619
نویسندگان
U. Bleul, B. Bircher, R.S. Jud, A.P.N. Kutter,