Selected diseases and conditions associated with bovine conceptus loss in the first trimester

The outcomes of insults to the bovine conceptus depend on the predilection of the insulting agent for the gravid reproductive tract, the virulence of the insult, and the developmental maturity/immune competence of the conceptus at the time of the insult. Agents that are lethal at one time during gestation may be harmless at another, or may have completely different effects (some not so harmless) at different gestational ages. This review discusses some of the known physical–mechanical, physiological, and infectious causes of first trimester bovine conceptus losses, including three infectious agents that have been the subject of recent studies for their potential to transmit disease via embryo transfer.