کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100491 1083003 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How closely related is graft-vs-leukemia to donor/recipient disparity?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
How closely related is graft-vs-leukemia to donor/recipient disparity?
چکیده انگلیسی

Graft-vs-host disease (GVHD) is an unwanted complication of stem cell transplant, but the graft-vs-leukemia (GVL) effect has been shown to positively affect outcomes. GVHD and GVL have similar but not identical alloreactivity, and GVL may be affected by the source of grafts, the preparative conditioning regimen, and donor genetic elements. Human leukocyte antigen (HLA) mismatch does not appear to augment the GVL effect, and increased GVHD does not necessarily lead to decreased relapse.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 23, Issue 4, December 2010, Pages 525–528
نویسندگان
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