کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2100611 | 1083012 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Immune-cell treatment of Epstein–Barr-virus-associated lymphoproliferative disorders Immune-cell treatment of Epstein–Barr-virus-associated lymphoproliferative disorders](/preview/png/2100611.png)
Lymphoproliferative disorders associated with Epstein–Barr virus (EBV) after bone-marrow or organ transplantation express all the immunogenic EBV antigens, and reduction in immunosuppressive treatment can result in permanent resolution. As such, the disease lends itself to EBV-directed immune-cell therapy. Successes have been achieved with both manipulated and unmanipulated T-cell infusions for lymphoproliferations occurring after bone-marrow transplantation. Several practical challenges have been overcome in applying EBV-specific T-cell therapy to the setting of organ-transplant-related lymphoproliferations. These include the generation of autologous cytotoxic T lymphocytes (CTLs), the creation of a partially HLA-matched cryopreserved allogeneic CTL bank, and the generation of autologous EBV-specific CTLs from EBV-naïve pediatric patients. The efficacy of immune-cell therapy in the setting of solid-organ transplantation is less well established than it is after T-cell-depleted allogeneic bone-marrow transplantation, and it is as yet not clear how to best to integrate CTL therapy with the anti-B-cell antibody rituximab, which has significant activity against these lymphoproliferations.
Journal: Best Practice & Research Clinical Haematology - Volume 19, Issue 4, December 2006, Pages 839–847