The emerging role of the transcriptional coregulator RIP140 in solid tumors

• The transcription factor RIP140 controls various nuclear oncogenic pathways.
• RIP140 is a main regulator of estrogen and E2F signalings in breast cancer cells.
• RIP140 regulates intestinal homeostasis by inhibiting the Wnt pathway.
• In colorectal cancers, low RIP140 expression is associated with poor prognosis.

RIP140 is a transcriptional coregulator (also known as NRIP1) which plays very important physiological roles by finely tuning the activity of a large number of transcription factors. Noticeably, the RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition. RIP140 is also involved in the regulation of various oncogenic signaling pathways and participates in the development and progression of solid tumors. This short review aims to summarize the role of this transcription factor on nuclear estrogen receptors, E2F and Wnt signaling pathways based on recent observations focusing on breast, ovary, liver and colon tumors.