کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2101086 1083104 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?
چکیده انگلیسی

There is a growing interest in understanding the complex interactions between bone marrow-derived myeloid-lineage cells and angiogenesis in tumors. Such interest has been revived recently by the observation that tumor-infiltrating myeloid cells convey proangiogenic programs that can counteract the activity of antiangiogenic drugs in mouse tumor models. Among myeloid cells, Tie2-expressing monocytes (TEMs) appear to have nonredundant function in promoting tumor angiogenesis and growth in mouse models. The identification and functional characterization of TEMs in mice and humans may provide novel molecular targets for anticancer therapy. Moreover, TEMs may be exploited to deliver antitumor drugs specifically to the tumor microenvironment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer - Volume 1796, Issue 1, August 2009, Pages 5–10
نویسندگان
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