کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2101291 1546250 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparison of Outcomes after Peripheral Blood Haploidentical versus Matched Unrelated Donor Allogeneic Hematopoietic Cell Transplantation in Patients with Acute Myeloid Leukemia: A Retrospective Single-Center Review
ترجمه فارسی عنوان
مقایسه نتایج پس از پیوند پیوندی سلول های هموپوئیدی آلوگن اهداکننده خون در محیط پیرامونی در بیمارانی که دارای لوسمی حاد میلوئید می باشند، بررسی شده است.
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Outcomes of MUD and peripheral blood haploidentical HCT have not been compared.
• Outcomes with the 2 approaches were compared in 140 allografted AML patients.
• In multivariate analysis, the only outcome difference was faster count recovery with MUD HCT.
• Peripheral blood haplo-HCT is a viable option for AML patients lacking a matched sibling.

Recent studies comparing allogeneic hematopoietic cell transplantation (HCT) using HLA-matched unrelated donors (MUD) versus HLA-haploidentical donors in patients with acute myeloid leukemia (AML) have suggested equivalent outcomes. The graft source used in most studies of haploidentical transplants has been bone marrow. Similar comparisons between MUD and haplo-HCT using peripheral blood as a graft source have not been adequately performed. We reviewed the records of all 52 AML patients who underwent haplo-HCT (using peripheral blood and post-transplantation high-dose cyclophosphamide) between January 2010 and August 2015 at our institution and compared their outcomes with 88 patients who had a MUD transplant in the same time frame and were frequency matched (preanalysis) to the haploidentical group for conditioning intensity. Multivariate analysis found no difference in outcomes between the 2 groups with the exception of slower count recovery after haploidentical allografts (HR, .48; 95% CI, .32 to .74 for platelets, and HR, .47; 95% CI, .32 to .71 for neutrophils; P < .001 for both comparisons). Our retrospective analysis, although limited by the small sample size, suggests largely similar outcomes with peripheral blood haploidentical versus MUD transplants for AML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 22, Issue 9, September 2016, Pages 1696–1701
نویسندگان
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