کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2101459 1546268 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New Cancers after Autotransplantations for Multiple Myeloma
ترجمه فارسی عنوان
سرطان های جدید بعد از اتلوپلاستی برای بیماری های مختلف
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• We analyzed incidence of new cancers in 4161 myeloma autotransplant recipients.
• The incidence rate of new cancers was 1.2 per 100 person-years.
• Overall incidence was similar to an age, sex, and race-adjusted US population.
• Acute myeloid leukemia and melanoma were observed at higher than expected rates.
• Obesity, age, and male sex were associated with new cancer in multivariate models.

We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7 years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P = .0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 21, Issue 4, April 2015, Pages 738–745
نویسندگان
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