کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2105222 1546399 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biology and Treatment of Multiple Myeloma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Biology and Treatment of Multiple Myeloma
چکیده انگلیسی

Multiple myeloma (MM) is a B cell malignancy that accounts for 10% of all hematologic cancers. In recent years much has been learned regarding the biology of the myeloma clone; specifically on the chromosomal alterations that can be more frequently found and on the involved oncogenes. It has been also demonstrated that, in MM, bone marrow microenvironment, both in its cellular (stromal cells, osteoblasts, osteoclasts, endothelia) and protein (extracellular matrix) components, plays an important role in promoting growth and survival of malignant plasma cells. Much of this knowledge will be translated into a better patients treatment; although high-dose therapy programs can be considered the treatment of choice for patients aged 70 or younger, novel drugs, targeting MM clone in its microenvironment can be incorporated into these therapeutic programs improving response rate and patients survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 12, Issue 1, Supplement 1, January 2006, Pages 81–86
نویسندگان
, , ,