کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2106262 | 1083495 | 2010 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Current therapeutic approaches to fungal infections in immunocompromised hematological patients Current therapeutic approaches to fungal infections in immunocompromised hematological patients](/preview/png/2106262.png)
SummaryInvasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this complication, but Aspergillus spp. and Candida spp. are the most frequently isolated micro-organisms; less commonly, infections could be caused by Zygomycetes or other rare molds or yeasts.Several new systemically-administered antifungal agents have been approved for clinical use since 2001; these agents include liposomal amphotericin B, voriconazole, caspofungin, and posaconazole, and they represent a major advance in antifungal therapy and have improved the prognosis of patients with hematological malignancies.This review focuses on therapeutic aspects of the management of fungal infections in hematological patients.
Journal: Blood Reviews - Volume 24, Issue 2, March 2010, Pages 51–61