کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2106320 1083503 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulating the regulators in cancer-immunosuppression in multiple myeloma (MM)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Regulating the regulators in cancer-immunosuppression in multiple myeloma (MM)
چکیده انگلیسی

An effective immune response requires a prompt but measured action against the pathological insult, to prevent over-zealous inflammatory-mediated tissue destruction. In cancer, defective or incompetent immune responses may paradoxically result in disease progression despite an immune attempt at elimination. Tumour-induced immunosuppression may not only result from soluble factors and altered antigenicity, but also from cellular-mediated tumour-induced immune evasion.Multiple myeloma (MM) is associated with both cellular and humoral immune deficiencies and increased TReg cells. In vitro modelling has indicated that the tumour cells directly induce functional TReg cells. In light of this recent evidence, it now seems that the most promising and synergistic approaches for cancer immunotherapy would involve specific anti-tumour immunity and simultaneous reduction of tumour-induced immune-regulation. This review sets out the basic understanding of the human immune response, its dysregulation in cancer and proposes how this knowledge may influence future treatment strategies to maximise the anti-tumour immune response.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Reviews - Volume 27, Issue 3, May 2013, Pages 155–164
نویسندگان
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