کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2106524 1083521 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Manipulation of vascular function by blood flukes?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Manipulation of vascular function by blood flukes?
چکیده انگلیسی

Schistosomes (blood flukes) are long lived, intravascular parasites that afflict ~ 200 million people worldwide. Here we review the potential ability of these parasites to exert control on local vascular physiology. We examine schistosome kallikrein-like proteins that drive vasodilation. We review biogenic amine metabolism in the parasites that involve the vasodilator histamine and its receptors and the vasoconstrictor serotonin and its receptor. Schistosomes can trigger the release of histamine from host cells and can import serotonin. We consider the ability of schistosomes to generate and release the eicosanoid vasodilators PGD2 and PGE2 and the vasoconstrictors LTB4 and LTC4. The literature on nitric oxide metabolism in these blood flukes is assessed. Finally the potential impact of other schistosome metabolic processes (e.g. exogenous adenosine generation and acetylcholine degradation) on vascular function is appraised. An increased understanding of these processes could lead to novel anti-parasitics as well as new therapies to treat vascular dysfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Reviews - Volume 25, Issue 4, July 2011, Pages 175–179
نویسندگان
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