کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2108351 | 1083770 | 2010 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma](/preview/png/2108351.png)
SummaryWe have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.
► Identification of a CpG island methylator phenotype (G-CIMP) in gliomas
► G-CIMP is tightly associated with IDH1 mutation
► G-CIMP patients are younger at diagnosis and display improved survival
► G-CIMP is more prevalent among low- and intermediate-grade gliomas
Journal: - Volume 17, Issue 5, 18 May 2010, Pages 510–522