کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2108621 1083802 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A concise review of serum markers for hepatocellular cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A concise review of serum markers for hepatocellular cancer
چکیده انگلیسی

Background: The rising incidence of hepatocellular cancer in the US and worldwide has sparked a renewed interest in HCC serum markers. HCC typically develops in patients with chronic liver disease and cirrhosis. It is in these target populations that serum markers are most urgently needed. Unfortunately, the currently available markers lack sensitivity and specificity. A number of novel candidate markers have recently been introduced. Methods: We performed a review of the literature (2001–2006) of traditional and novel serum markers for hepatocellular cancer. Results: Several promising new HCC markers have been identified over the past 5 years. They include single proteins, complex proteomics features, and tumor-specific autoantibodies. The excitement about the new markers is tempered by the realization that none of them have yet met the most stringent criteria defined by the Early Detection Research Network (EDRN). Conclusion: A new generation of HCC serum markers awaits validation in properly controlled clinical studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Detection and Prevention - Volume 31, Issue 1, 2007, Pages 35–44
نویسندگان
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