کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2110393 | 1546555 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Replication of results of a genome-wide association study on lung cancer survival in a Korean population
ترجمه فارسی عنوان
تکرار نتایج یک مطالعه مرتبط با ژنوم در مورد بقای سرطان ریه در یک جمعیت کره ای
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کلمات کلیدی
بررسی ارتباط ژنوم، سرطان ریه سلول غیر سلولی، پلی مورفیسم، بقای،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
چکیده انگلیسی
Recently, a genome-wide association study (GWAS) identified single nucleotide polymorphisms (SNPs) that may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS on lung cancer survival in a Korean population. A total of 363 patients with surgically resected NSCLCs were enrolled, and 12 SNPs were genotyped using the SEQUENOM MassARRAY iPLEX assay, TaqMan assay, or a polymerase chain reaction-restriction fragment length polymorphism analysis. The association between genotypes and overall survival (OS) was analyzed. Among the 12 SNPs, the rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed a better OS than the patients with the rs6034368T allele (adjusted hazard ratio = 0.72, confidence interval = 0.56-0.93, P = 0.01). The rs12446308A>G had an effect on OS, but it was marginally significant (under a codominant model, adjusted hazard ratio = 1.85, confidence interval = 0.98-3.47, P = 0.06). We identified that the rs6034368T>C was associated with survival in early-stage NSCLC in a Korean population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 207, Issues 1â2, JanuaryâFebruary 2014, Pages 35-39.e2
Journal: Cancer Genetics - Volume 207, Issues 1â2, JanuaryâFebruary 2014, Pages 35-39.e2
نویسندگان
Seung Soo Yoo, Mi Jeong Hong, Hyo-Sung Jeon, Won Kee Lee, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Eungbae Lee, Jae Yong Park,