کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112245 1084357 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heterogeneity of liver cancer and personalized therapy
ترجمه فارسی عنوان
عدم همبستگی سرطان کبد و درمان شخصی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Among the tumors that so far have been identified, liver cancer is highly heterogeneity one.
• Variable natural history, environmental susceptibilities, and genetic predispositions all contribute to the heterogeneity.
• Morphological diversity, signal transduction network and microenvironmental discrepancies characterized by the heterogeneity.
• The heterogeneity of liver cancer should be modified and refined to diagnose and treat patients in a personalized manner.

Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk factors such as HBV and/or HCV infections, aflatoxin infection, abuse alcohol intake, metabolic syndrome, obesity and diabetes are closely related to the environmental and genetic susceptibilities to HCC. The consequent resulting genomic instability, molecular and signal transduction network disorders and microenvironmental discrepancies are characterized by the extraordinary heterogeneity of liver cancer. The histology-based definition of the morphological heterogeneity of liver cancer has been modified and refined to treat patients with targeted therapies, but this still cannot solve all the problems. Lack of consistent outcome for anticancer agents and conventional therapies in liver cancer treatment calls for assessing the benefits of new molecularly targeted drugs and combined therapy, under the heterogeneity condition of tumor. The present review article will provide the complex mechanism and phenotype of liver cancer heterogeneity, and help us to execute precision medicine in a really personalized manner.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 379, Issue 2, 1 September 2016, Pages 191–197
نویسندگان
, ,