کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2112541 | 1084395 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology
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کلمات کلیدی
CFE, colony forming efficiencyCNS, central nervous system - CNS، سیستم عصبی مرکزیCOX-2, cyclooxygenase-2 - COX-2، cyclooxygenase-2DSBs, double strand breaks - DSBs، شکست دو رشتهHR, homologous recombination - HR، recombination homologousIL-1, interleukin-1 - IL-1، اینترلوکین-1HCC, hepatocellular carcinoma - کارسینوم هپاتوسلولار
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology](/preview/png/2112541.png)
چکیده انگلیسی
Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 34–42
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 34–42
نویسندگان
Vasiliki I. Hatzi, Danae A. Laskaratou, Ifigeneia V. Mavragani, Zacharenia Nikitaki, Anastasios Mangelis, Mihalis I. Panayiotidis, Gabriel E. Pantelias, Georgia I. Terzoudi, Alexandros G. Georgakilas,