Role of β-Catenin in regulating the balance between TNF-α- and Fas-induced acute liver injury

β-Catenin plays many critical roles during various liver physiological and pathological processes. However, the role of β-Catenin in acute liver failure remains unclear. Using hepatocyte specific β-Catenin knockout mice, we found that loss of β-Catenin in hepatocyte significantly reduced GalN/LPS-induced liver damage and hepatocyte apoptosis, but exacerbated Jo2-mediated liver injury. Mechanistically, the dual effects of β-Catenin attributes on its function of inhibiting NF-κB signaling, which aggravates oxidative stress but decreases Fas expression under injury conditions. In conclusion, β-Catenin plays an important role in regulating the balance between TNF-α and Fas-induced liver injury via its effect on NF-κB.

► β-Catenin aggravates GalN/LPS induced liver injury.
► β-Catenin protects hepatocytes from Fas induced liver injury.
► Interaction with NF-κB modulates the role of β-Catenin in acute liver injury.