کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113101 1084442 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells
چکیده انگلیسی

Abnormal cytokinesis increases the possibility of nuclear fusion in tumor cells. However, the role of microRNAs (miRNAs) in abnormal cytokinesis is unclear. Here, we found that miR-1290 was significantly up-regulated in clinical colon cancer tissues. Up-regulation of miR-1290 postponed cytokinesis and led to the formation of multinucleated cells. KIF13B was a target of miR-1290 that was involved in aberrant cytokinesis. Furthermore, enforced expression of miR-1290 activated the Wnt pathway and increased the reprogramming-related transcript factors c-Myc and Nanog. Our results suggest that up-regulation of miR-1290 in colon cancer cells impaired cytokinesis and affected reprogramming.


► miR-1290 is up-regulated in colon cancer cells.
► Up-regulation of miR-1290 impairs cytokinesis.
► miR-1290 overexpression affects the reprogramming of colon cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 329, Issue 2, 28 February 2013, Pages 155–163
نویسندگان
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