کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113101 | 1084442 | 2013 | 9 صفحه PDF | دانلود رایگان |

Abnormal cytokinesis increases the possibility of nuclear fusion in tumor cells. However, the role of microRNAs (miRNAs) in abnormal cytokinesis is unclear. Here, we found that miR-1290 was significantly up-regulated in clinical colon cancer tissues. Up-regulation of miR-1290 postponed cytokinesis and led to the formation of multinucleated cells. KIF13B was a target of miR-1290 that was involved in aberrant cytokinesis. Furthermore, enforced expression of miR-1290 activated the Wnt pathway and increased the reprogramming-related transcript factors c-Myc and Nanog. Our results suggest that up-regulation of miR-1290 in colon cancer cells impaired cytokinesis and affected reprogramming.
► miR-1290 is up-regulated in colon cancer cells.
► Up-regulation of miR-1290 impairs cytokinesis.
► miR-1290 overexpression affects the reprogramming of colon cancer cells.
Journal: Cancer Letters - Volume 329, Issue 2, 28 February 2013, Pages 155–163