کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113368 1084463 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
چکیده انگلیسی

Pyruvate kinase M2 (PKM2) is a rate-limiting enzyme of aerobic glycolysis in cancer cells and plays important roles in cancer metabolism and growth. Here we show that vitamin K3 and K5 (VK3 and VK5) are relatively specific PKM2 inhibitors. VK3 and VK5 showed a significantly stronger potency to inhibit PKM2 than to inhibit PKM1 and PKL, 2 other isoforms of PK dominantly expressed in most adult tissues and liver. This study combined with previous reports supports that VK3 and VK5 have potential as adjuvant for cancer chemotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 316, Issue 2, 28 March 2012, Pages 204–210
نویسندگان
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