کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113377 | 1084464 | 2012 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To better understand the response of HCC to EGFR inhibition, we analyzed factors connected to the resistance of HCC cells against gefitinib. Sensitive HCC3 cells co-expressed EGFR and ErbB3 but lacked kinase-domain mutations in EGFR. Interestingly, expression of MVP was restricted to resistant cell lines, whereas ABCB1 and ABCC1 showed no association with gefitinib resistance. Moreover, ectopic MVP expression in HCC3 cells decreased gefitinib sensitivity, increased AKT phosphorylation and reduced the expression of inflammatory pathway-associated genes, whereas silencing of MVP in Hep3B and HepG2 cells increased sensitivity. These findings suggest MVP as a novel player in resistance against EGFR inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 319, Issue 2, 28 June 2012, Pages 164–172
Journal: Cancer Letters - Volume 319, Issue 2, 28 June 2012, Pages 164–172
نویسندگان
Annemarie Losert, Daniela Lötsch, Andreas Lackner, Herwig Koppensteiner, Barbara Peter-Vörösmarty, Elisabeth Steiner, Klaus Holzmann, Thomas Grunt, Katharina Schmid, Brigitte Marian, Bettina Grasl-Kraupp, Rolf Schulte-Hermann, Georg Krupitza,