کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113449 | 1084469 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Suppression of c-Myc is likely to induce cellular senescence in many tumors with unclear mechanisms. A proteomics survey indicated that high levels of BCL2-associated athanogene 2 (BAG2) were found in response to c-Myc repression in TRE293 cells. This observation led to the investigation into the role of BAG2 in c-Myc-induced senescence. The association of the c-Myc/SP1 complex with the BAG2 promoter verified the role of c-Myc/SP1 in regulating BAG2 transcription. Furthermore, high levels of BAG2 were found to induce p21CIP1-dependent senescence and subsequent carcinogenetic arrest, suggesting its possible role as an indirect activator of the p21CIP1 pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 318, Issue 1, 1 May 2012, Pages 34–41
Journal: Cancer Letters - Volume 318, Issue 1, 1 May 2012, Pages 34–41
نویسندگان
Ju Zhang, Xiaomin Lou, Shangbin Yang, Shun He, Lei Yang, Mei Liu, Hongxia Zhu, Qiang Shan, Siyuan Su, Qimin Zhan, Ningzhi Xu, Siqi Liu,