کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113464 | 1084470 | 2011 | 11 صفحه PDF | دانلود رایگان |
HPV-16 infection may play an important role in the development of non-small cell lung cancer (NSCLC) among never-smokers. Due to the critical role of angiogenesis in NSCLC development, we describe here the effect of HPV-16 oncoproteins on angiogenesis in NSCLC and the underlying mechanisms. We found that overexpression of HPV-16 E6 and E7 oncoproteins in NSCLC cells significantly promoted angiogenesis both in vitro and in vivo, and correspondingly, an enhanced expression of HIF-1α and VEGF, important pro-angiogenic factors in tumor angiogenesis. Meanwhile, overexpression of HPV-16 oncoproteins also led to HIF-1α-dependent increases in the secretion of several other pro-angiogenic factors, including IL-8. Our findings suggest that HPV-16 oncoproteins contribute to the development of NSCLC possibly by promoting HIF-1α/VEGF-mediated tumor angiogenesis.
► Overexpression of HPV-16 oncoproteins in NSCLC cells promoted angiogenesis.
► Overexpression of HPV-16 oncoproteins enhanced HIF-1α protein accumulation.
► Overexpression of HPV-16 oncoproteins increased VEGF protein and mRNA expression.
► HPV-16 oncoproteins-induced VEGF and IL-8 expression was HIF-1α-dependent.
Journal: Cancer Letters - Volume 311, Issue 2, 8 December 2011, Pages 160–170