کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113591 | 1084479 | 2011 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo](/preview/png/2113591.png)
Neuromedin B (NMB), a member of the mammalian bombesin-like peptide family, and its receptor were aberrantly expressed in vascularized solid tumors. Here, the NMB receptor (NMB-R) antagonist PD168368 specifically inhibited both NMB-induced in vivo and in vitro angiogenesis. In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. Overall, NMB-R antagonist exhibited a significant antitumor activity by simultaneously inhibiting neovascularization and cancer cell growth, thereby suggesting that NMB-R could be a potential therapeutic target for cancer treatment.
► Neuromedin B (NMB) receptor antagonist PD168368 inhibits NMB-induced endothelial angiogenesis in vitro and in vivo.
► PD168368 reduces viability and xenograft tumor growth of human MDA-MB-231 breast cancer cells.
► PD168368 induces cell cycle arrest and apoptosis in MDA-MB-231 cells.
► PD168368 exerts antitumor activity through the inhibition of tumor growth and angiogenesis.
Journal: Cancer Letters - Volume 312, Issue 1, 15 December 2011, Pages 117–127