کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113640 | 1084484 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro antitumor activity of silybin nanosuspension in PC-3 cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro antitumor activity of silybin nanosuspension in PC-3 cells In vitro antitumor activity of silybin nanosuspension in PC-3 cells](/preview/png/2113640.png)
چکیده انگلیسی
The present study aims to evaluate the antitumor activity of silybin nanosuspension on human prostatic carcinoma PC-3 cell line in vitro. Silybin nanosuspension was prepared by the high pressure homogenization (HPH) method. MTT assay, observation of morphological changes and apoptotic body showed that silybin nanosuspension could significantly enhance the in vitro cytotoxicity against PC-3 cells compared to the silybin solution. Flow cytometric (FCM) analysis demonstrated that silybin nanosuspension induced G1 cycle arrest and apoptosis in PC-3 cells. Thereby, the overall results suggest that the silybin nanosuspension represents a potential source of medicine for the treatment of human prostate cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 307, Issue 2, 28 August 2011, Pages 158–164
Journal: Cancer Letters - Volume 307, Issue 2, 28 August 2011, Pages 158–164
نویسندگان
Dandan Zheng, Yancai Wang, Dianrui Zhang, Zhaoping Liu, Cunxian Duan, Lejiao Jia, Feihu Wang, Yue Liu, Guangpu Liu, Leilei Hao, Qiang Zhang,