کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113769 | 1084493 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thyroid hormone as a regulator of tumor induced angiogenesis Thyroid hormone as a regulator of tumor induced angiogenesis](/preview/png/2113769.png)
Thyroid hormones (TH) – 3,5,3′-triiodo-l-thyronine (T3) and l-thyroxine (T4) – are important regulators of differentiation, growth, metabolism, and physiological function in most tissues. TH have been also implicated in cellular transformation, tumorigenesis and metastasis, assuming particular importance in tumor induced angiogenesis. TH-induced angiogenesis is thought to be initiated at integrin αvβ3 membrane receptor mainly through T4 binding. The reduction of TH in circulation or the inhibition of TH actions at the integrin αvβ3 receptor would consequently produce a reduction on the proliferative and angiogenic TH effects. Therefore, targeting TH actions could be an alternative adjuvant therapy against cancer proliferation and angiogenesis.
Journal: Cancer Letters - Volume 301, Issue 2, 28 February 2011, Pages 119–126