کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113980 | 1084510 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells RXRγ and PPARγ ligands in combination to inhibit proliferation and invasiveness in colon cancer cells](/preview/png/2113980.png)
Nuclear retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs are potential candidates as drug target for cancer prevention and treatment. We investigated if the rexinoid 6-OH-11-O-hydroxyphenantrene (IIF) potentiates the antitumoral properties of PPARγ ligands as ciglitazone and pioglitazone, on two colon cancer cell lines: HCA-7 and HCT-116. Drugs inhibited cell growth and induced apoptosis synergistically. The combination resulted in a decrease of cyclooxigenase-2, metalloproteinases-2 and -9 expression level and activity while PPARγ, RXRγ and tissue inhibitors of metalloproteinase-1 and -2 expression were increased. Finally, IIF potentiated PPAR transcriptional activity by enhancement of peroxisome proliferator response elements transactivation.
Journal: Cancer Letters - Volume 297, Issue 1, 1 November 2010, Pages 65–74