کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113985 1084510 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo
چکیده انگلیسی

The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 297, Issue 1, 1 November 2010, Pages 109–116
نویسندگان
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