کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114069 | 1084515 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antitumor activity of novel fluoro-substituted (–)-epigallocatechin-3-gallate analogs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Epidemiological studies support the cancer-preventive effects of green tea and its main constituent (–)-epigallocatechin gallate [(–)-EGCG], however, (–)-EGCG is unstable under physiological conditions. Here we report that two novel fluoro-substituted (–)-EGCG analogs inhibited tumor growth with similar potency to that of Pro-EGCG (1) which has improved potency over parental compound (–)-EGCG in human breast cancer MDA-MB-231 xenografts. MDA-MB-231 tumors treated with each fluoro-substituted (–)-EGCG analog showed proteasome inhibition and apoptotic cell death, suggesting that the proteasome might be one of the cellular targets of fluoro-(–)-EGCGs and that proteasome inhibition is partially responsible for the observed antitumor activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 292, Issue 1, 1 June 2010, Pages 48–53
Journal: Cancer Letters - Volume 292, Issue 1, 1 June 2010, Pages 48–53
نویسندگان
Huanjie Yang, Dong Kui Sun, Di Chen, Qiuzhi Cindy Cui, Yan Yan Gu, Tao Jiang, Wei Chen, Sheng Biao Wan, Q. Ping Dou,