کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114079 1084515 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
p21Cip1 Confers resistance to imatinib in human chronic myeloid leukemia cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
p21Cip1 Confers resistance to imatinib in human chronic myeloid leukemia cells
چکیده انگلیسی

Imatinib is a Bcr-Abl inhibitor used as first-line therapy of chronic myeloid leukemia (CML). p21Cip1, initially described as a cell cycle inhibitor, also protects from apoptosis in some models. We describe that imatinib down-regulates p21Cip1 expression in CML cells. Using K562 cells with inducible p21 expression and transient transfections we found that p21 confers partial resistance to imatinib-induced apoptosis. This protection is not related to the G2-arrest provoked by p21, a decrease in the imatinib activity against Bcr-Abl or a cytoplasmic localization of p21. The results suggest an involvement of p21Cip1 in the response to imatinib in CML.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 292, Issue 1, 1 June 2010, Pages 133–139
نویسندگان
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