کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114441 1084538 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern
چکیده انگلیسی

At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC50 was found in GG than GT/A genotype (p = 0.02) and in G–C than G–T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G–C and G–T ABCB1 haplotypes. Ethnic differences in the G–T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 277, Issue 2, 18 May 2009, Pages 155–163
نویسندگان
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