کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114442 1084538 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer
چکیده انگلیسی

Circulating tumor cells (CTCs) hold promise for studying advanced prostate cancer. A functional collagen adhesion matrix (CAM) assay was used to enrich CTCs from prostate cancer patients’ blood. CAM ingestion and epithelial immuno-staining identified CTCs, which were genotyped using oligonucleotide array comparative genomic hybridization. The highest CTC counts were observed in men with metastatic castration resistant prostate cancer (CRPC) compared to castration sensitive prostate cancer. Copy number profiles for CRPC CTCs were similar to paired solid tumor DNA, and distinct from corresponding DNA from the residual CAM-depleted blood. CAM CTC enrichment may allow cellular and genetic analyses in prostate cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 277, Issue 2, 18 May 2009, Pages 164–173
نویسندگان
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