کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114450 1084538 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes
چکیده انگلیسی

To characterize the biological features of side population (SP) in oral squamous cell carcinoma (OCC), SP and non-SP were sorted and compared. The SP cells were more clonogenic and in nude mice, only 10,000 SP cells were needed for tumor development compared to 1,000,000 non-SP cells. The SP cells expressed higher levels of ABCG2, ABCB1, CD44, Oct-4, Bmi-1, NSPc1 and CK19. The SP cells generated SP and non-SP populations, whereas the non-SP cells generated only non-SP. These findings provide the first evidence that SP in OCC possesses tumor stem cell phenotypes and may play an important role in OCC tumorigenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 277, Issue 2, 18 May 2009, Pages 227–234
نویسندگان
, , , , ,