کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114585 | 1084546 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells](/preview/png/2114585.png)
چکیده انگلیسی
Transforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 274, Issue 1, 8 February 2009, Pages 101–108
Journal: Cancer Letters - Volume 274, Issue 1, 8 February 2009, Pages 101–108
نویسندگان
Lei Jiang, Yangchao Chen, Chu-yan Chan, Xin Wang, Lin Lin, Ming-liang He, Marie C.M. Lin, David T. Yew, Joseph J.Y. Sung, Ji-Cheng Li, Hsiang-fu Kung,