کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114619 1084547 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
In vitro cancer cell imaging and therapy using transferrin-conjugated gold nanoparticles
چکیده انگلیسی

Gold nanoparticles were conjugated with transferrin molecules for targeting, imaging and therapy of breast cancer cells (Hs578T, ATCC). Results show that, the transferrin–transferrin receptor-mediated cellular uptake of gold nanoparticles is six times of that in the absence of this interaction. As a consequence, the laser power effective for photothermal therapy of the cancer cells was reduced to values of two orders of magnitude lower. To demonstrate the efficiency of the conjugated gold nanoparticles in selectively targeting cancer cells, the cellular uptake of the gold nanoparticles by noncancerous cells (3T3, ATCC) was also investigated. The cellular uptake by the normal cells is only one fourth of that by the cancerous cells indicating that the transferrin–transferrin receptor interaction plays an important role in controlling the cellular uptake of the gold nanoparticles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 274, Issue 2, 18 February 2009, Pages 319–326
نویسندگان
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