کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114855 1084559 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny
چکیده انگلیسی
Here, we investigated the cell killing effectiveness of heavy-ion radiation in Bcl-2 overexpressing radioresistant tumor cells. First, irradiated cells underwent primary colony formation. Radioresistance decreased with increasing linear energy transfer (LET), indicating that heavy ions may be a promising therapeutic modality for Bcl-2 overexpressing tumors. Second, cells in primary colonies were reseeded for secondary colony formation. The incidence of delayed reproductive death increased with LET irrespective of Bcl-2 overexpression, suggesting that Bcl-2 overexpression may not facilitate heavy ion-induced genomic instability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 268, Issue 1, 8 September 2008, Pages 76-81
نویسندگان
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